(Regulation of blood sugar levels)
Trial 1: Diabetes
|Patient||age||sex||glucose the day before [mg/dl]||glucose after 24 h [mg/dl]|
Mode of action:
Glucose being taken up from the gut in the blood has to be transported quickly to cells for keeping glucose concentration in blood constant. In muscle cells glucose is used to gain energy. In fat cells glucose builds fat reserves and in liver cells it builds glycogen, as a quickly available glucose reserve. The hormone insulin from Langerhans’ islet cells in the pancreas increases permeability of cell membranes for glucose. A lack of insulin or a resistance of cell membranes increases blood sugar level (diabetes mellitus). The counterpart of insulin is adrenaline, causing a quick availability of glucose. The most frequent form of diabetes is a form of exhaustion of insulin-building cells (diabetes mellitus type 2). This is a frequent disease in industrial nations, especially in higher ages. In some cases, it can be controlled by dietetic means, while in other cases insulin has to be substituted.
It is known (Khan et al. 2003) that cinnamon in daily doses, in quantities of grams, reduce serum glucose levels but also triglycerides, LDL-cholesterol and total cholesterol. Due to research (Wei et al. 2008; Babu, Prabuseenivasan, Ignacimuthu 2006) cinnamon aldehyde is responsible for removing insulin resistance. The drop of lipids can be traced back to mevalonic acid (Babu, Prabuseenivasan, Ignacimuthu 2006). In most hormone regulated systems, two antagonistic hormones are responsible for control. Therefore adrenaline is also promoted. The allyl-isothiocyanetes (sinigrin, sinalbin) from onion, mustard and cabbage are agonists of thermo-sensitive-receptor-potential-channels (Iwasaki et al. 2008) resulting in an excretion of adrenaline. They are natural beta-2-adreno-receptor-agonists. Unfortunately, cinnamon as well isothiocyanates have an intensive smell, limiting for sensoric reasons the uptake in necessary amounts. Both substances are semi-conductors and can therefore be used for bio-active quantum dots (Gradl 2008), reducing the necessary quantities. These substances are used in dimuSAN.
Extract of cinnamon, (cinnamaldehyde) being sympatho-mimetics (Chen et al 2008; Zijlstra, Patience 2004) improve fattening performance while reducing protein degradation simultaneously. Allyl-isothiocyanates (sinigrin, sinalbin) from onion, mustard or crucifers as well as cinnamaldehyde are agonists of thermosensitive receptor-potential channels (Iwasaki et al. 2008), causing adrenalin release. They are natural β-2 adreno-receptor agonists.
Unfortunately, these substances show an intensive smell and taste, limiting the uptake for sensory reasons. Cinnamaldehyde as well as isothiocyanates are physical semi conducers and are therefore principally suitable to produce quantum dots (Gradl 2008). Hence, it is possible to reduce necessary quantities drastically and in addition all active ingredients enter the cellular ion channels of the muscular system within minutes now.