Case Studies

naturCortisan | Anti-inflammatory, pain relief

Anti-inflammatory, pain relief
Case studies:

(Anti-inflammatory, pain relief)

Trial 1:

Using the mentioned combination of incense, curcuma and line seed oil for two to eight weeks, 61 patients were treated. Their ages were between 26 and 92 years. 48 patients (27 female, 21 male) had chronic complaints of the locomotive system (joint and back complaints) and 13 patients had other complaints.

Joint and back problems:

From 48 patients with chronic diseases of the locomotive system after treatment time, 5 were without symptoms, 2 cases had no change, but 17 patients improved and 24 improved significantly with pain relief.

Other indication:

The results of 13 patients with other indications were:

  • Morbus Crohn (N=6) improved in 1 case and improved significantly in 5 cases after3-6 weeks.

This option shall be used because in cm cortisol, immune-suppressers and TNF alpha blockers are used, all of them with severe side effects.

  • Autoimmune thyroiditis (N=1) Improved after two weeks.
  • Multiple allergies/fibromyalgie/ Migraine (N=1)Improved after 3 weeks.
  • Periodontitis (N=1)Improved significantly after 4 weeks.
  • Chronic obstructive lung disease COPD, coronary heart disease KHK, peripheral arterial occlusive disease (N=1)Improved after 4 weeks. The treatment of COPD is of interest because inhalative corticosteroids do not help.
  • Migraine (N=2)Significant improvement after 2 and 4 weeks
  • Asthma bronchial (N=1)Significant improvement

Trail 2:

19 persons suffering from rheumatic diseases received 3 capsules (450 mg each) a day for 2-6 weeks. In 14 cases the symptoms improved and they had pain relief. In two cases, no control was possible. Only 2 cases had a slightly diminished condition.

Age Sex Dignosis Duration of treatment (weeks) Better/worse Remarks
42 M arthritis: hip. ev. polyarthritis 3 +++
37 M arthritis: foot 4
72 F arthritis: shoulder, elbow 4 +++
68 F spine degeneration, angina 6 ++
53 M muscular rheumatoid: shoulder, neck 5 ? no control
49 M muscular rheumatoid: pelvis 4 +/-
38 M arthritis: finger 4 ++
42 F arthritis: hip 4 ++
56 F arthritis: spine 3 ++ relapse after finishing the treatment
55 M polyarthritis 5
60 F arthritis: shoulder, elbow 4 ++
42 F arthritis: hip 4 ++
40 F arthritis: shoulder 4 ? no control
42 F pelvis, degeneration of spine 3 ++
62 F arthritis: foot 2 +
53 M polyarthrosis 4 ++
50 M arthritis: hand finger 4 +
41 F arthrosis: breastbone 6 +++
48 M arthritis: finger 4 ++

*scaling:

much worse (—); significantly worse (–); worse (-); equal (+/-); better (+);significantly better (++); without symptoms (+++)

Mode of action:

For RA several pathogeneses are discussed. Mostly accepted is the assumption or significant participation of an immune pathogenesis. T-lymphocytes activate synovial macrophages, secreting inflammatory cytokines TNF-α and IL-1, causing by that way osteoclasts and chondrocytes to destroy cartilage and bone in a pincer movement. In a vicious circle chondrocytes produce big quantities of FGF and GM-CSF, which again stimulates macrophages. The control is performed via the HPA-Axis (Turnbull, Rivier 1999) where IL-1 and TNF-α stimulates the formation of CRH in the hypothalamus. CRH causes in the pituitary gland the formation of ACTH, which causes the adrenal cortex to produce corticosteroids.

There are two possibilities. In one case the pituitary gland reacts to CRH and AVP excretion of the hypothalamus by promoting the inflammatory reaction by prolactin and MIF. In the other case the adrenal cortex is caused by ACTH to produce cortisol and DHEAS (Cutolo, 2002). In this way a positive feed-back reaction can be avoided in which IL-6, IL-1 and TNF-α from the inflammation stimulates the hypothalamus. This mechanism seems to play an important role in rheumatic diseases. Instead of using corticosteroids for RA-therapy for some years, blockers of TNF-α (Anakinra; Kineret) are used. It is supposed that by using cytokine-blockers, fewer side effects can occur than by using corticosteroids. On the other hand blocked cytokines also play an important role in other parts of the body besides RA-inflammation. Susceptibility to infections is higher during this therapy. Research of Aggarwal (1999) and Mukhopadhyay et al. (2001) showed that natural substances like curcumin (from curcuma roots) can inhibit the formation of cytokines. The mechanism is an inhibition of the activation of NFκB-transkriptionsfactor. The phytotherapeutic use of other pungent flavors in RA-therapy like gingerol from ginger or eugenol from cloves may be based on the same effect.

Pungent flavors used orally in higher concentrations or for a longer period can cause unpleasant side-effects Therefore they are used as quantum dots.

Boswellic acids of incense are acting via 5-lipooxygenase to reduce leukotriene synthesis in a non-competitive, reversible way (Mack et al 1991, Safayhi et al 1992, Ammon HPT 1998, Ammin HPT 2006). Additionally, it is known for thousands of years that boswellic acids are anxiolytic, support pain relief, and promote regeneration in a parasympathetic way. Another advantage is that it is well tolerated (Porihar et al 1997).

Clinical studies in India using extracts of Boswellia serrata in inflammatory in gut diseases (colitis ulcerosa) revealed that it is as good as the standard-therapeutic Sulfasalazin (Porihar et al 1997, Gupta et al 2001). These positive results could also be seen in morbus Crohn (Gerhord et al 2001). In asthma bronchial 300 mg of Boswellia serrata per day increased respiratory volume fivefold in a placebo controlled study with 40 patents (Gupta et al 2001).

Also, curcuma (curcumin as active ingredient) reduced leukotriene synthesis. Simultaneously lipid peroxidation and therefore cell wall damages could be inhibited (Huong et al 1991).

Even thousands of years ago, in Egypt the healing power of curcuma against liver and bile diseases as well as in bladder and kidney diseases and in leprosy had been known.

Curcumin protects significantly of proteinuria, hypalbuminaemia and hyperlipidaemia. Simultaneously the enzyme Glutathione S-transferase increases, an important factor for detoxification activity (Goedeke et al 2004).

In two double-blind studies an antiphlogistic activity of curcumin and phenylbutazone could be found. In this trial 400 mg Curcumin were equal to 100 mg phenylbutazone. A comparison of 500 mg curcumin to Na-diclofenac showed, in 45 patients suffering from rheumatoid arthritis, that curcumin was superior- without side effects.

In 2011 3934 studies using curcumin existed revealing astonishing effects (Louis PF 2013).

Compatibility of curcumin is optimal even at doses of 8 g daily. In a study with cancer patients no side effects could be seen.

Line seed oil consists of 45-71% omega-3 fatty acids (alpha-linoic acid (ALA) and 12% omega-6 fatty acids (linoleic acid). These essential nutrients are transformed in the liver to omega-3 fatty acids and arachidonic acid. In the body alpha-linoic acid is transformed to docosahexaen acid (DHA) and eicosapentaen acid (EPA) (Sinopoulos AP 2002). Linoleic acid is transformed to dihomogamma linoic acid (DGLA) and arachidonic acid (AA). EPA and DGLA are transformed to eicosanoids that inhibit inflammation while AA shows the reverse activity. Therefore, alpha linoic acid (in contradiction to linoleic acid) inhibits inflammations, because enzymatic activity is attracted. Instead of arachidonic acid, eicosanoids are formed.

The inhibition of inflammation by omrga-3 fatty acids stabilizes metabolism, the hormone system, and promotesthe immune system: It does not block or destroy like anti-rheumatics, base therapeutics and biologicals. Instead of health damaging side effects DHA stabilizes membranes, especially nerve cells, and promotes thinking capacity (Nielsson et al 2012, Portillo-Reyes et al 2014). Therefore DHA is represented by 90% in the brain and retina. The latter is the reason for treating macular degeneration according to age (AMD) by DHA (Georgiou et al 2014). Simultaneously DHA harmonizes blood pressure and heart frequency and reduces blood clotting, blood fat and blood glucose levels. It also reduces the risk for strokes (Nielsson et al 2012, Honsen-Krone et al 2014).

naturCortisan, Anti-inflammatory, for pain relief

 

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